Lymph node, spleen and peripheral blood lymphocytes as stimulators of alloreactivity.

Lymphocyte transformation of peripheral blood lymphocytes and plaque forming cells of the spleen and the mesenteric lymph node in suckling piglets with and without immunopotentiators.

Thymic cytotoxic T lymphocytes are primed in vivo to minor histocompatibility antigens

Potent cytotoxic T lymphocyte (CTL) activity can be derived from cultures of thymocyte responders and minor H different spleen cell stimulators. As is the case of the spleen cell response previously reported, this cytotoxic activity requires in vivo priming. We performed several experiments designed to determine whether the in vivo priming effect is due to the in situ priming of the thymocyte C...

Distribution of Labeled Lymph Node Cells in Mice during the Lymphocytosis Induced by Bordetella Pertussis

The mechanism by which Bordetella pertussis organisms and their products induce lymphocytosis in mice was analyzed in terms of the localization of syngeneic Cr-51-labeled lymph node cells. Labeled lymphoid cells incubated in vitro with the supernatant of B. pertussis cultures and then injected intravenously into normal recipients, or labeled cells injected into pertussis-treated recipients were...

Differences in Cyclic AMP Changes after Stimulation by Prostaglandins and Isoproterenol in Lymphocyte Subpopulations.

Various lymphocyte populations have been studied for their content in cyclic adenosine 3',5'-monophosphate (cAMP) before and after stimulation by isoproterenol and prostaglandin E(1) (PGE(1)). Basal cAMP levels vary among lymphocytes according to their origin: peripheral blood lymphocytes show high cAMP level while spleen and lymph node cells and thymocytes show lower levels. Thymocytes are ext...

Biol. Pharm. Bull. 29(12) 2343—2349 (2006)

Lymphocytes are generated in primary lymphoid organs, such as the bone marrow and thymus, and migrate to the lymph nodes, Peyer’s patches, and spleen, known as secondary lymphoid organs, where the immune responses occur. Lymphocytes that migrate to the lymph nodes and Peyer’s patches emigrate through the efferent lymph, unless they encounter their cognate antigens. Lymphocytes that emigrate thr...